"Iran will never change its policies in the region under US sanctions and pressure," Zarif said in an interview with the Doha-based Al Jazeera broadcaster on Monday.
Emphasizing that Washington must lift the bans on Tehran, Iran's foreign minister said, "Iran will never hold negotiations about its missile program, because our missiles do not threaten anybody."
President Donald Trump said on July 30 that he is ready to meet his Iranian counterpart, Hassan Rouhani, “any time they want to.”
Elsewhere in his interview, Zarif said the US has launched an economic war against Iran and Turkey, emphasizing that Tehran would fully stand by Ankara in its confrontation with Washington.
Leader of the Islamic Revolution Ayatollah Seyyed Ali Khamenei said on Monday that the Islamic Republic will not enter into new negotiations with the United States due to cheating and bullying nature of its government.
Speaking in a meeting with a large group of Iranian people in Tehran, Ayatollah Khamenei dismissed talks with the US, saying Washington is only after concessions.
In a live televised interview on August 6, Iranian President Hassan Rouhani said the US administration is no more able to prove its trustworthiness for any negotiations after its withdrawal from a landmark nuclear agreement, officially known as the Joint Comprehensive Plan of Action (JCPOA), in May and a number of other international treaties.